Lead / Sr. Engineer, Genomics Device Development and Manufacturing

Product/Process development - Waltham, MA - Permanent

Company Description

Honeycomb Biotechnologies is an early-stage company focused on creating and commercializing scalable solutions for
storage and single cell genomic analysis of precious clinical samples. We enable translation of the rich biological
information encoded in clinical specimens into high-resolution digital information, which can be queried and analyzed with
sequencing. The resulting exponential growth in knowledge about the state of each person’s health and disease will
enable the identification of new therapies and better targeting of current medicines in the era of precision medicine. Our
first product is the “HIVE” – a single-use disposable device that is used (without any Honeycomb-specific instrumentation
or equipment) for capturing, storing, and profiling transcripts (i.e., RNA) with single-cell resolution. Come join our team
focused on providing basic and clinical researchers with better solutions for understanding health and disease.

Position Summary

We are seeking a candidate with excellent communication and technical skills and a high aptitude for product development and product-specific manufacturing process development. This candidate will play a critical role in innovation and development of our current and next generation picowell array devices for storage and analysis of samples at single cell resolution. Working closely with the rest of the Honeycomb team, the successful candidate will use their technical and problem-solving skills to define and refine the design and manufacturing parameters, fabricate, test and characterize prototype designs, and facilitate transfer of the design to high volume and scalable manufacturing. This role is central to the ongoing success of the company.

Responsibilities & Essential Functions

  • Leadership and individual contributions to consumable design, prototyping, optimization, and transfer to high-volume manufacturing
    • Oversight of consumable device development
    • CAD and prototyping of devices
    • Optimization of microscale elements using photolithography
    • Integration and testing of macro- and microfluidic elements
  • Development and refinement of molded custom components for single-use devices
  • Interfacing with internal staff and external partners to develop and support reliable and scalable manufacturing
  • Guidance and promotion of a quality system that enables organized and efficient product development, disciplined high-quality manufacturing, and a strong standard of quality control and documentation practices
  • Implementation of basic statistics principles for data analysis and experimental design
  • Support innovation and IP creation


  • Training in Mechanical, Chemical, or Biomedical Engineering, or Material Sciences, or equivalent field
  • Minimum of 5 years of hands-on post-degree experience
  • Fluency in CAD software
  • Aptitude for creative problem solving and innovation
  • Good communication, interpersonal, teamwork, and supervisory skills
  • Enthusiasm to work in a fast-paced startup company with minimal supervision to be productive
  • Authorization to work in the United States
Apply for this Job