Single-Cell Bioinformatician / Scientist

Research & Development - Waltham, MA - Permanent

Company Description

Honeycomb Biotechnologies is an early-stage company focused on creating and commercializing scalable solutions for storage and single cell genomic analysis of precious clinical samples. We enable translation of the rich biological information encoded in clinical specimens into high-resolution digital information, which can be queried and analyzed with sequencing. The resulting exponential growth in knowledge about the state of each person’s health and disease will enable the identification of new therapies and better targeting of current medicines in the era of precision medicine. Our first product is the “HIVE” – a single-use disposable device that is used (without any Honeycomb-specific instrumentation or equipment) for capturing, storing, and profiling transcripts (i.e., RNA) with single-cell resolution. Come join our team focused on providing basic and clinical researchers with better solutions for understanding health and disease.

Position Summary

We are seeking a candidate with excellent computational and data analysis skills and a high aptitude for applications and technologies for single-cell genomics. The position will play a role in development, optimization, validation, and support of products (including software) and protocols. Specific responsibilities will include: (1) bioinformatics processing and analysis of single-cell datasets; (2) participating in the development and support of analysis pipelines and customer-facing software; (3) analysis of experiments and projects that develop, test, and optimize molecular biology workflows; and (4) perform root cause analysis and troubleshooting support of customer applications and data.

Responsibilities & Essential Functions

  •  Execute primary analysis pipeline(s) and examine datasets (secondary analysis) to detect signals associated with technology and assay performance 
  •  Record data and findings according to stage-dependent practices and policies 
  •  Communicate results to management and core team members 
  •  Summarize studies and results in whitepapers and/or presentations 
  •  Implement basic statistics principles and quantitative reasoning for data analysis and experimental design 
  •  Expand and refine computational pipelines for streamlined performance 
  •  Provide bioinformatics-related customer support and troubleshooting as part of a larger support team 
  •  Support innovation and IP creation 
  •  Adhere to quality system requirements and safety compliance 


  • Degree and training in Biology, Bioinformatics, Computer Science, or related discipline or equivalent work experience, or related field (MS preferred, or BS with relevant experience will be consider

  • Experience with standard bioinformatics analysis tools/packages/pipelines (single-cell experience preferred)

  • Ability to quickly learn about new science and technology fields

  • Comfortable in fast-paced and dynamic environment of an early-stage company

  • Aptitude for creative problem-solving and excellent troubleshooting skills

  • Excellent organization and task planning skills

  • Good communication, interpersonal and teamwork skills

  •  Self-starter who requires minimal supervision to be productive

  • Authorization to work in the United States 

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