Emerging technologies for single cell genomics

Capture precious samples anywhere — even at clinical network edges

Lock-in biological states and store as long as needed

Process centrally for better efficiency and reduced variability

cell drives

Genomic resolution at the individual cell level is powering the next phase of precision health. Honeycomb offers a new paradigm in single-cell technology—cell drives for the collection and storage of biological samples for asynchronous single-cell analysis. Founded on pioneering nanowell technology from MIT, our HIVE Cell Drives enable scalable and cost-effective single-cell interrogation of samples, with the efficiency and quality of centralized analytical processing. Honeycomb aims to expand single-cell opportunities in discovery, diagnostics, and monitoring to clinical settings throughout the world.


Cellular expression changes rapidly, so we lock in signal at point and time of collection.

Honeycomb devices require no complex equipment or training so samples can be can be collected in almost any setting.

Gentle stabilization process allows even the most fragile cells to be captured.


HIVE drives preserve biological information in a single cell format (similar to storing digital information in computer drives).

Honeycomb devices maintain sample integrity during storage, shipping, and eventual processing.

This asynchronous feature of single-cell storage let’s you control where and when samples are profiled.

Centralized Processing

Honeycomb single-cell devices enable samples to be processed centrally, which improves efficiencies and reduces variabilities.

While Honeycomb does not rely on a complex processing instrument, our devices are designed to work with all major automated liquid handling workflows.

Honeycomb’s open array format allows for a variety of profiling applications beyond just single-cell RNA-seq.

Use Cases

Distributed collection

HIVE drives are ideal for collecting samples in multi-center clinical studies.

Fragile cell types

Honeycomb’s array-based cell isolation format has successfully been used to capture even the most delicate or labile types of cells (granulocytes, nephrons, hepatocytes, and neurons)

Sparse samples

Precious samples containing only a few thousand cells — or even a few hundred — can be successfully profiled with Honeycomb’s HIVE drives.

Founded by world leaders
in single-cell technology

Jim Flanigon, PhD, MBA

Chief Executive Officer

Life science and technology executive. Expertise in genomics, molecular diagnostics, and precision medicine, including roles at Genzyme, CCE, and Oracle.

Todd Gierahn, PhD

Chief Science Officer

Single-cell and immunology pioneer. MIT senior researcher on single-cell technologies. Developed foundational platform for Genocea Biosciences.

Brian Hutchison, PhD

Sr. VP Development & Ops

Life science operations executive. Genomic development and operations leader at Qiagen and Rain Dance.

Alex K. Shalek, PhD

massachusetts institute of technology

Pfizer-Laubach Career Development Assistant Professor, IMES and Chemistry at MIT. Leader in the development of new technologies for deep, integrated molecular profiling of cells and their interactions.

J. Christopher Love, PhD

massachusetts institute of technology

Professor of Chemical Engineering at Koch Institute for Integrative Cancer Research at MIT. Focus on technologies that address biological questions in immunology, microbiology, systems biology, and bioprocess engineering.

© 2019 Honeycomb Biotechnologies, Inc.