Organoids connect different cell types in a three-dimensional network that resembles the source organ. Brain organoids generally contain neurons and glial cells but can be tuned to model specific brain regions to capture cell dynamics with sufficient biological complexity to study neuroinflammation & other brain diseases. The HIVE helps researchers scale organoid studies to tease out biological diversity from technical variability.

Researchers at the AIBN (Australian Institute for Bioengineering & Nanotechnology, University of Queensland) chose the HIVE™ Single Cell Solution to analyze transcriptomes of different cell types within brain organoids. Across months of culture, they processed organoids & froze cell-loaded HIVEs to consolidate their RNAseq, reducing technical variability in their data & immediately yielding growth trajectories for their models.